Many object to embryo selection because they mistakenly believe it involves altering genes. In reality, the technology simply reveals information about natural genetic variations already present in IVF embryos, allowing parents to choose, not tinker.

Up to 40% of natural conceptions are spontaneously aborted, often before a woman knows she's pregnant. This is typically the body's way of rejecting embryos with severe genetic abnormalities. This natural process provides a powerful biological precedent for the practice of pre-implantation genetic screening.

An internal Nucleus Genomics experiment revealed that when 16 employees chose from 8 embryos, there were 14 unique selections. This demonstrates that 'optimization' is based on highly personal values, countering the fear that genetic selection will lead to a human monoculture.

Standard IVF practice involves a doctor visually selecting the embryo that appears most "normally shaped." This is already a form of selection. Polygenic screening simply replaces this subjective "eyeballing" method with quantitative genetic data for a more informed choice, making it an evolution, not a revolution.

Fears that embryo selection will create a uniform human population are misplaced. The process is a *relative* optimization, limited to the genetic diversity provided by the two parents. The choice of partner has a far more significant impact on the gene pool than selecting among resulting embryos.

It is now possible to combine the nuclear DNA from a mother and father with the mitochondrial DNA from a third-party egg donor. This "three-parent IVF," approved in the UK for mitochondrial diseases, creates a child with the genetic makeup of two parents and the mitochondrial health of a third.

The ability to select embryos fundamentally changes parenthood from an act of acceptance to one of curation. It introduces the risk of "buyer's remorse," where a parent might resent a child for not living up to their pre-selected potential. This undermines the unconditional love that stems from accepting the child you're given by fate.

Nucleus Genomics is moving beyond adult personal genomics into the ethically charged market of IVF embryo selection. This represents a strategic pivot from providing personal health insights to actively influencing reproductive choices, signaling a search for more impactful and potentially lucrative applications.

The complaint 'I would have been selected against' is logically incoherent. Any change in conception—including embryo selection—creates a different person. One cannot be 'harmed' by a choice that results in their non-existence; they are simply replaced by another potential person. The complaining 'you' would never have existed.