Smart Biotech Scientist | Master Bioprocess CMC Development, Biologics Manufacturing & Scale-up, Cell Culture Innovation

Episodes

228: Media-Based Glycan Engineering for Biosimilars: Your Rapid Implementation Guide

February 17, 2026

Master glycan engineering with raffinose. This guide provides an 8-week, 3-experiment protocol to increase high mannose for biosimilar matching.

227: Media-Based Glycan Engineering for Biosimilars: Achieving Reference Product Match

February 10, 2026

Raffinose in media increases high-mannose glycans 2.8x, solving biosimilar glycan mismatch without cell re-engineering or inhibitors.

226: Mastering Radiopharmaceutical Development: Preclinical Model Selection for Clinical Success with Bryan Miller - Part 2

February 5, 2026

Radiopharmaceuticals are entering a new era, driven by theragnostics, advanced preclinical models (PDX), and strategic CRO partnerships.

225: Mastering Radiopharmaceutical Development: Preclinical Model Selection for Clinical Success with Bryan Miller - Part 1

February 3, 2026

Mastering radiopharmaceutical development requires precise preclinical models to overcome unique challenges in this rapidly growing oncology field.

224: From Cultivated Meat to Chocolate: Rethinking Cellular Agriculture Scale-Up with Steven Lang - Part 2

January 29, 2026

Cellular agriculture is more than lab meat. Explore scaling cacao & coffee to meet global food demand, focusing on simpler, safer products.

223: From Cultivated Meat to Chocolate: Rethinking Cellular Agriculture Scale-Up with Steven Lang - Part 1

January 27, 2026

Steven Lang of California Cultured explains how producing cacao from plant cells offers a cost-effective, scalable vision for cellular agriculture.

222: From 2D Cultures to Advanced 3D Cell Models for Preclinical Research with Catarina Brito - Part 2

January 22, 2026

Advanced 3D cell models reveal therapeutic resistance missed by 2D cultures, offering a more predictive preclinical research platform.

221: From 2D Cultures to Advanced 3D Cell Models for Preclinical Research with Catarina Brito - Part 1

January 20, 2026

Catarina Brito explains why bioprocess must be biology-first, pioneering advanced 3D cell models to replace traditional preclinical methods.

220: From 10,000 Structures to 1.8 Billion Interactions: Breaking the Data Bottleneck to Engineer Efficacious Therapeutics with Troy Lionberger - Part 2

January 15, 2026

From 10k structures to 1.8B interactions, A-alpha Bio's platform breaks the data bottleneck, fueling AI to engineer complex therapeutics.

219: From 10,000 Structures to 1.8 Billion Interactions: Breaking the Data Bottleneck to Engineer Efficacious Therapeutics with Troy Lionberger - Part 1

January 13, 2026

A-AlphaBio's Troy Lionberger explains how measuring millions of protein interactions and using AI transforms antibody discovery from years to months.

218: Silkworm Biomanufacturing: From Ancient Silk Production to Phase I Vaccine Trials with Masafumi Osawa - Part 2

January 8, 2026

Silkworm pupae are being repurposed as living bioreactors to produce complex vaccines and proteins, offering a fast, scalable, and low-cost platform.

217: Silkworm Biomanufacturing: From Ancient Silk Production to Phase I Vaccine Trials with Masafumi Osawa - Part 1

January 6, 2026

Kaiko pioneers silkworm biomanufacturing, turning these ancient creatures into powerful, consistent bioreactors for vaccines and complex proteins.

216: From Data Silos to Autonomous Biomanufacturing: Digital Twins and AI-Driven Scale-Up with Ilya Burkov - Part 2

December 18, 2025

AI is transforming biomanufacturing from data silos to smart factories. Start small with clean data and leverage cloud computing for scale.

215: From Data Silos to Autonomous Biomanufacturing: Digital Twins and AI-Driven Scale-Up with Ilya Burkov - Part 1

December 16, 2025

AI is shifting bioprocessing from an experimental to a computational science. Digital twins and ML are slashing timelines & de-risking scale-up.