In treating conditions like heart failure, Gordian's approach is not to replace damaged cells but to use gene therapy to "reprogram" existing, dysfunctional ones. This strategy aims to restore the normal function of the patient's own tissue rather than engaging in the more complex task of rebuilding it.

Life operates on a finite energy budget divided between vital functions, stress responses, and growth/maintenance/repair (GMR). Energy allocated to stress is directly diverted from GMR, meaning chronic stress actively prevents your body from healing, repairing, and growing.

The company's therapy uses transient engineering with a single mRNA strand to deliver both anti-inflammatory and anti-fibrotic payloads into a patient's own macrophages. This enhances the cells' natural healing abilities, aiming to reduce inflammation and resolve fibrotic scars to allow organs like the liver to regenerate.

Standard liver panels check ALT and AST, but Gamma-glutamyl transferase (GGT) is a more sensitive marker for liver stress, particularly from alcohol or certain supplements. It often elevates before other enzymes, acting as a 'canary in the coal mine' for potential liver issues.

For millennia, humans consumed weak, fermented beverages in communal settings, providing natural limits. The recent inventions of distillation (high-potency alcohol) and cultural shifts toward private, isolated consumption have removed these biological and social guardrails, making alcohol far more dangerous than it was historically.

The pattern of alcohol consumption significantly impacts liver health. Large, sudden surges of alcohol from binge drinking episodes can be more acutely harmful than chronically drinking at a moderate level. These intense episodes create a large buildup of toxic byproducts that the liver struggles to clear, potentially accelerating damage.

Cellular senescence is a biological process that permanently halts cell division. Contrary to being just a sign of aging, its primary function is to prevent damaged cells from becoming cancerous. It's a protective measure that stops unchecked proliferation when a cell cannot repair its own damage or undergo programmed cell death.

Senescent cells are not inactive; they are metabolically active and secrete inflammatory molecules known as SASP (Senescence-Associated Secretory Phenotype). This initially helps clear damage, but as these cells accumulate with age, the chronic inflammation they cause can worsen diseases like Alzheimer's, heart disease, and liver fibrosis.

Dr. Will Bolsiewicz distinguishes between life-saving acute inflammation (fighting infection, healing injury) and detrimental chronic low-grade inflammation. The latter is a constant, damaging immune response likened to a “forever war” inside the body, which is at the root of many modern diseases.