McCullough's most non-consensus belief is that the era of the "captain stock picker" is ending. He argues that massive, systematic macro flows have become the dominant force in markets, overriding the individual fundamental merits of a company. This suggests understanding the macro environment is now more important than traditional bottom-up analysis.

A powerful market signal is the "quad count," or the forecasted sequence of economic regimes. A progression from Quad 4 (recession fears) to Quad 3 and then to Quads 2 and 1 creates a powerful contrarian setup. This allows investors to buy assets like small caps when recession probabilities are priced at their highest.

Don't dismiss megatrends like demographics and technology as only long-term concerns. Research from Vanguard's Joe Davis shows these forces account for roughly 60% of quarter-to-quarter changes in per capita GDP growth and earnings yield, making them immediate drivers of the business cycle.

Emerging vs. developed market outperformance typically runs in 7-10 year cycles. The current 14-year cycle of EM underperformance is historically long, suggesting markets are approaching a key inflection point driven by a weakening dollar, cheaper currencies, and accelerating earnings growth off a low base.

Before AI delivers long-term deflationary productivity, it requires a massive, inflationary build-out of physical infrastructure. This makes sectors like utilities, pipelines, and energy infrastructure a timely hedge against inflation and a diversifier away from concentrated tech bets.

Policymakers can maintain market stability as long as inflation volatility remains low, even if the absolute level is above target. A spike in CPI volatility is the true signal that breaks the system, forces a policy response, and makes long-term macro views suddenly relevant.

Joe Davis argues the economy faces a "tug of war" between an AI-driven boom and a deficit-fueled slump. He believes the mainstream forecast of stable 2% growth and 2% inflation is the least likely outcome, with an over 80% chance of a material change in the economic environment.

Contrary to popular belief, Vanguard's chief economist suggests that in a high-debt, low-growth future, overweighting fixed income is superior to holding gold. This assumes the Fed will maintain high real interest rates to fight inflation, making bond yields more attractive than equities, which would face a lost decade.

According to Keith McCullough, historical backtesting reveals the rate of change of the U.S. dollar index is the most critical macro factor for predicting performance across asset classes. Getting the dollar right provides a significant edge in forecasting moves in commodities, equities, and other global markets.