Wet lab experiments are slow and expensive, forcing scientists to pursue safer, incremental hypotheses. AI models can computationally test riskier, 'home run' ideas before committing lab resources. This de-risking makes scientists less hesitant to explore breakthrough concepts that could accelerate the field.

Foundation models can't be trained for physics using existing literature because the data is too noisy and lacks published negative results. A physical lab is needed to generate clean data and capture the learning signal from failed experiments, which is a core thesis for Periodic Labs.

OpenAI announced goals for an AI research intern by 2026 and a fully autonomous researcher by 2028. This isn't just a scientific pursuit; it's a core business strategy to exponentially accelerate AI discovery by automating innovation itself, which they plan to sell as a high-priced agent.

To make genuine scientific breakthroughs, an AI needs to learn the abstract reasoning strategies and mental models of expert scientists. This involves teaching it higher-level concepts, such as thinking in terms of symmetries, a core principle in physics that current models lack.

Companies like OpenAI and Anthropic are not just building better models; their strategic goal is an "automated AI researcher." The ability for an AI to accelerate its own development is viewed as the key to getting so far ahead that no competitor can catch up.

The ultimate goal for leading labs isn't just creating AGI, but automating the process of AI research itself. By replacing human researchers with millions of "AI researchers," they aim to trigger a "fast takeoff" or recursive self-improvement. This makes automating high-level programming a key strategic milestone.

Instead of relying on digital proxies like code graders, Periodic Labs uses real-world lab experiments as the ultimate reward function. Nature itself becomes the reinforcement learning environment, ensuring the AI is optimized against physical reality, not flawed simulations.

Current LLMs fail at science because they lack the ability to iterate. True scientific inquiry is a loop: form a hypothesis, conduct an experiment, analyze the result (even if incorrect), and refine. AI needs this same iterative capability with the real world to make genuine discoveries.

The next leap in AI will come from integrating general-purpose reasoning models with specialized models for domains like biology or robotics. This fusion, creating a "single unified intelligence" across modalities, is the base case for achieving superintelligence.