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  1. Huberman Lab
  2. Essentials: How to Build, Maintain & Repair Gut Health | Dr. Justin Sonnenburg
Essentials: How to Build, Maintain & Repair Gut Health | Dr. Justin Sonnenburg

Essentials: How to Build, Maintain & Repair Gut Health | Dr. Justin Sonnenburg

Huberman Lab · Dec 11, 2025

Dr. Sonnenburg reveals how diet shapes your gut microbiome, highlighting fermented foods as a key tool to boost diversity and lower inflammation.

A 'Healthy' Western Microbiome May Actually Be a Pre-Disease State

Studies of traditional populations show their microbiomes are vastly different from those in industrialized nations. This suggests that what is considered a 'healthy' American microbiome might actually be a perturbed state, silently predisposing individuals to chronic inflammatory and metabolic diseases due to factors like antibiotics and diet.

Essentials: How to Build, Maintain & Repair Gut Health | Dr. Justin Sonnenburg thumbnail

Essentials: How to Build, Maintain & Repair Gut Health | Dr. Justin Sonnenburg

Huberman Lab·2 months ago

Gut Cleanses Are a 'Russian Roulette' for Microbiome Health

While cleanses or flushing protocols effectively wipe out the existing gut microbial community, they leave the repopulation process entirely to chance. This creates a vulnerable period where you might end up with a better or worse microbial community, making it a high-risk gamble unless you have a specific, targeted plan for recolonization.

Essentials: How to Build, Maintain & Repair Gut Health | Dr. Justin Sonnenburg thumbnail

Essentials: How to Build, Maintain & Repair Gut Health | Dr. Justin Sonnenburg

Huberman Lab·2 months ago

Emulsifiers in Processed Foods Directly Erode the Gut’s Protective Mucus Barrier

Beyond lacking nutrients, processed foods contain additives like emulsifiers that are actively harmful. These chemicals, added for shelf stability, are known to disrupt the gut's critical mucus layer. This erosion of the natural barrier between your gut microbes and your body can directly lead to inflammation and contribute to metabolic syndrome.

Essentials: How to Build, Maintain & Repair Gut Health | Dr. Justin Sonnenburg thumbnail

Essentials: How to Build, Maintain & Repair Gut Health | Dr. Justin Sonnenburg

Huberman Lab·2 months ago

Purified Prebiotic Supplements Can Paradoxically Decrease Gut Diversity

Unlike the complex fibers from whole foods, purified prebiotics can cause a bloom of a small number of bacteria specialized in consuming that single fiber type. This can lead to an overall decrease in microbial diversity as these few specialists outcompete other microbes. A wide variety of plant foods is a safer approach to fostering a diverse gut ecosystem.

Essentials: How to Build, Maintain & Repair Gut Health | Dr. Justin Sonnenburg thumbnail

Essentials: How to Build, Maintain & Repair Gut Health | Dr. Justin Sonnenburg

Huberman Lab·2 months ago

Your Microbiome Has a 'Biological Gravity' That Resists Lasting Change

The gut microbiome exists in a stable state with a resilience that makes it difficult to alter permanently. After short-term disruptions like antibiotics or diet changes, it often 'snaps back' to its original composition. This means meaningful, long-term change requires sustained effort to establish a new, stable microbial state rather than temporary interventions.

Essentials: How to Build, Maintain & Repair Gut Health | Dr. Justin Sonnenburg thumbnail

Essentials: How to Build, Maintain & Repair Gut Health | Dr. Justin Sonnenburg

Huberman Lab·2 months ago

Fermented Foods Increase Gut Diversity and Lower Inflammation More Than Fiber Alone

In a head-to-head study, a diet high in fermented foods like yogurt and kimchi significantly increased microbiome diversity and lowered markers of inflammation. A high-fiber diet did not consistently produce these effects, suggesting that introducing live microbes is a more direct strategy for improving gut health and immune status in Western populations.

Essentials: How to Build, Maintain & Repair Gut Health | Dr. Justin Sonnenburg thumbnail

Essentials: How to Build, Maintain & Repair Gut Health | Dr. Justin Sonnenburg

Huberman Lab·2 months ago

High-Fiber Diets Can Fail if Your Gut Lacks Fiber-Digesting Microbes

Increasing fiber intake may not improve gut health if an individual's microbiome is already depleted. Research suggests many people in the industrialized world have lost the specific microbes needed to break down diverse fibers. Without these microbes, the fiber passes through without providing benefits, highlighting the need to first restore microbial diversity.

Essentials: How to Build, Maintain & Repair Gut Health | Dr. Justin Sonnenburg thumbnail

Essentials: How to Build, Maintain & Repair Gut Health | Dr. Justin Sonnenburg

Huberman Lab·2 months ago