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  1. Making Sense with Sam Harris
  2. #463 — Privatizing the Apocalypse
#463 — Privatizing the Apocalypse

#463 — Privatizing the Apocalypse

Making Sense with Sam Harris · Mar 11, 2026

How a podcast and a bipartisan coalition dismantled 'Deep Vision,' a government biosecurity project with the potential to 'cancel civilization.'

Discovering Deadly Viruses Preemptively Is Counterproductive Without Safe Vaccine Testing

The rationale for "virus hunting" is to create advance vaccines. However, you cannot safely test a vaccine for a novel, deadly pathogen on healthy humans. This makes the knowledge unactionable for prevention, while creating immense risk by bringing dangerous pathogens into leaky labs and publicizing their existence.

#463 — Privatizing the Apocalypse thumbnail

#463 — Privatizing the Apocalypse

Making Sense with Sam Harris·4 days ago

Well-Meaning 'Do-Gooders,' Not Terrorists, Can Pose the Greatest Existential Risks

The Deep Vision project, which had the potential to "cancel civilization," was conceived by well-intentioned officials at USAID, not malicious actors. This reveals that catastrophic risk can emerge from groups trying to solve problems, who are completely blind to the dangerous second-order effects of their work.

#463 — Privatizing the Apocalypse thumbnail

#463 — Privatizing the Apocalypse

Making Sense with Sam Harris·4 days ago

Publishing Pathogen Genomes Creates an Unvettable Global Threat from Thousands of Individuals

Deep Vision's plan to publish the genomes of deadly viruses would effectively give the "killing power of a nuclear arsenal" to an estimated 30,000 unvetted individuals with synthetic biology skills. In the bio-age, openly publishing certain information can be a greater security threat than physical weapons.

#463 — Privatizing the Apocalypse thumbnail

#463 — Privatizing the Apocalypse

Making Sense with Sam Harris·4 days ago

Averting USAID's Risky 'Deep Vision' Project Required an Unlikely Bipartisan Coalition

The successful campaign to stop the high-risk Deep Vision project was not a top-down decision. It involved a loose, cross-partisan alliance initiated by podcasters and thinkers, then actioned by figures ranging from Chelsea Clinton to Senators Lindsey Graham and Rand Paul, demonstrating the power of quiet, multi-pronged pressure.

#463 — Privatizing the Apocalypse thumbnail

#463 — Privatizing the Apocalypse

Making Sense with Sam Harris·4 days ago

A Coordinated Multi-Pathogen Release Could Collapse Society By Disabling Frontline Workers

A malevolent actor using a published list of deadly viruses could release multiple pathogens at once from many locations. This would overwhelm medical systems and, most critically, cause societal collapse when essential frontline workers refuse to risk their lives and families for their jobs, shutting down the supply of food, power, and law enforcement.

#463 — Privatizing the Apocalypse thumbnail

#463 — Privatizing the Apocalypse

Making Sense with Sam Harris·4 days ago

All Biosecurity Labs, Even High-Security Ones, Leak at an Unknown Rate

A core flaw in virus hunting is moving pathogens from isolated natural environments to labs in dense population centers. Despite security ratings, all categories of labs have a history of leaks. The lack of a uniform reporting system means we don't know the failure rate, making labs a riskier container than nature.

#463 — Privatizing the Apocalypse thumbnail

#463 — Privatizing the Apocalypse

Making Sense with Sam Harris·4 days ago