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The people who stayed with the problem

The people who stayed with the problem

The Top Line · Sep 4, 2026

The Fierce 50 highlights innovators tackling healthcare's biggest challenges, from 'undruggable' cancers to rebuilding public health trust.

Revolution Medicines' CEO Shows Breakthroughs Require Managing Doubt, Not Eliminating It

RevMed's CEO, Mark Goldsmith, admits to significant doubts when betting the company on an "undruggable" target. His philosophy is that scientific progress requires having doubts, but not so many that they paralyze action. This mindset is crucial for pursuing high-risk, high-reward innovation and reframes doubt as a necessary component rather than a barrier.

The people who stayed with the problem thumbnail

The people who stayed with the problem

The Top Line·a month ago

Health Misinformation Stems from Patient Shame, Not Just Malicious Actors

Physician Lisa Fitzpatrick argues that much misinformation isn't nefarious. It arises when patients are too embarrassed to admit they don't understand complex medical information. They then construct their own narratives using sources they trust. This reframes the problem from fighting deception to prioritizing clear, shame-free communication and building trust.

The people who stayed with the problem thumbnail

The people who stayed with the problem

The Top Line·a month ago

To Diversify Senior Roles, Dr. Mary Owen Says Investment Must Start in K-12, Not University Recruiting

Dr. Mary Owen observes that by the time organizations recruit from universities for specialized roles, the pool of diverse candidates is already tiny. To truly solve the workforce pipeline problem, she argues for starting much earlier by getting K-12 students interested and creating a clear path for them long before they apply to college.

The people who stayed with the problem thumbnail

The people who stayed with the problem

The Top Line·a month ago

Public Health Innovator Michael Osterholm Credits Progress to Ignoring Perceived Constraints

When explaining his team's rapid success on complex projects, like publishing a massive evidence review in three months, Michael Osterholm credits a kind of productive naïveté. He suggests that sometimes progress happens simply because a team isn't aware that what they're attempting is considered impossible or isn't "supposed to be done."

The people who stayed with the problem thumbnail

The people who stayed with the problem

The Top Line·a month ago

The Medium is The Medicine: Hip-Hop Public Health Proves Delivery Matters as Much as Data

The success of Hip-Hop Public Health demonstrates that accurate medical information is useless if not delivered via a memorable and trusted medium. By using catchy music from cultural icons, they ensure critical health guidance is not just heard, but also understood, retained, and trusted by the target community, making the communication format a key part of the intervention.

The people who stayed with the problem thumbnail

The people who stayed with the problem

The Top Line·a month ago