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The Hidden Bottleneck in Drug Discovery You Need to Fix NOW

The Hidden Bottleneck in Drug Discovery You Need to Fix NOW

Drug Diaries · Jan 25, 2026

Stop optimizing every part of your system. Dr. Alan Bernard explains how to find and fix the single bottleneck holding you back using the Theory of Constraints.

Management Attention, Not Time or Capital, Is an Organization's Ultimate Bottleneck

Management theorist Herbert Simon predicted that the primary constraint would shift from data availability to our ability to process it. For leaders, this means their limited, focused attention is the scarcest resource. How this attention is allocated determines the entire organization's performance and success.

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The Hidden Bottleneck in Drug Discovery You Need to Fix NOW

Drug Diaries·25 days ago

Improving Every 'Link' in Your System Is Wasteful; Focus Only on the Weakest One

The traditional approach of improving every component of a system is a reductionist fallacy. A system's performance is dictated by its single biggest constraint (the weakest link). Strengthening other, non-constrained links provides no overall benefit to the system's output and is therefore wasted effort.

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The Hidden Bottleneck in Drug Discovery You Need to Fix NOW

Drug Diaries·25 days ago

Frame Project Delays in Dollars Per Day to Overcome Bureaucratic Inertia

In high-stakes projects like clinical trials, waiting for a scheduled weekly meeting can be an absurdly expensive convenience. Calculating and constantly referencing the 'cost of delay'—which can be millions per day—reframes the problem, creating the urgency needed to get an immediate decision instead of waiting.

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The Hidden Bottleneck in Drug Discovery You Need to Fix NOW

Drug Diaries·25 days ago

Shatter Limiting Beliefs by Asking Your Team, 'This Goal is Impossible, Unless...?'

Labeling a goal 'impossible' is a defense mechanism that shuts down creative thinking. The framing 'it's impossible, unless…' bypasses this block. It acknowledges the difficulty while immediately prompting the mind to search for the specific conditions or actions that would make the goal achievable, turning a dead end into a brainstorm.

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The Hidden Bottleneck in Drug Discovery You Need to Fix NOW

Drug Diaries·25 days ago

Diagnose Your Core Bottleneck Sequentially: Demand, Capacity, Supply, Cash, Attention

A company's growth is limited by one of five constraints in a specific hierarchy. Leaders should diagnose them sequentially. First, ask if you have enough demand. If not, that's your only focus. Once solved, move to internal capacity, then external supply, then cash, and finally management attention.

The Hidden Bottleneck in Drug Discovery You Need to Fix NOW thumbnail

The Hidden Bottleneck in Drug Discovery You Need to Fix NOW

Drug Diaries·25 days ago

Pushing for 99% 'Busyness' Can Delay a One-Day Task by 100 Days

Organizations often incentivize high resource utilization, believing busyness equals productivity. However, queueing theory shows that as utilization nears 100%, wait times for new tasks explode exponentially. This focus on local efficiency kills system-level flow, creating massive, costly delays in critical processes like drug discovery.

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The Hidden Bottleneck in Drug Discovery You Need to Fix NOW

Drug Diaries·25 days ago

New Tech Fails When You Don't Dismantle the Old Rules Built Around Former Limitations

Technology only adds value if it overcomes a constraint. However, organizations build rules and processes (e.g., annual budgeting) to cope with past limitations (e.g., slow data collection). Implementing powerful new tech like AI will fail to deliver ROI if these legacy rules aren't also changed.

The Hidden Bottleneck in Drug Discovery You Need to Fix NOW thumbnail

The Hidden Bottleneck in Drug Discovery You Need to Fix NOW

Drug Diaries·25 days ago

Market Leaders Like Tata Steel Use TOC to Fight Complacency by Benchmarking Against History

For top-performing companies, the biggest risk is inertia. The Theory of Constraints (TOC) helps them fight this by exposing the gap between their current 'best' and what is theoretically possible. Tata Steel benchmarked its 9-month supply chain against Henry Ford's 81-hour cycle from 1926 to create urgency for radical improvement.

The Hidden Bottleneck in Drug Discovery You Need to Fix NOW thumbnail

The Hidden Bottleneck in Drug Discovery You Need to Fix NOW

Drug Diaries·25 days ago