Historically a Democratic focus, drug pricing policy has been co-opted by Republicans, making it a bipartisan political issue. This alignment creates a stable policy overhang and sustained uncertainty around pricing and innovation, deterring generalist investors regardless of which party is in power.

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Both Democrats and Republicans avoid the boring, complex solutions to inflation—like housing density, healthcare reform, and aggressive antitrust. Instead, they opt for politically palatable but ineffective measures like tariffs (Republicans) or short-term subsidies (Democrats), ensuring the core problems remain unsolved.

By negotiating prices down from over $1,000 to as low as $150 per month, the government deal fundamentally shifts Ozempic's market position. It is no longer a high-end luxury akin to plastic surgery but an accessible wellness product comparable to a fancy gym membership, dramatically expanding its addressable market.

A paradoxical market reality is that sectors with heavy government involvement, like healthcare and education, experience skyrocketing costs. In contrast, less-regulated, technology-driven sectors see prices consistently fall, suggesting a correlation between intervention and price inflation.

Recent elections show a clear pattern: politicians win by focusing on groceries, rent, and healthcare. These three categories, dubbed the "unholy trinity," represent the biggest inflation pain points and make up 55% of the average American's cost of living, making them the decisive political issue.

Senator Warren notes that resistance to banning congressional stock trading isn't confined to one political party. She observes that politicians from both sides of the aisle have been resistant to passing new laws, making it a bipartisan problem that requires voter pressure to solve.

While patents are important, a pharmaceutical giant's most durable competitive advantage is its ability to navigate complex global regulatory systems. This 'regulatory know-how' is a massive barrier to entry that startups cannot easily replicate, forcing them into acquisition by incumbents.

A centrist solution to high drug prices involves combining ideas from both political aisles. Oliver Libby suggests allowing Medicare to negotiate prices (a left-leaning idea) while also extending patent life for drug companies (a right-leaning idea), thus lowering costs without killing the incentive for innovation.

The healthcare sector's current struggles are not a recent phenomenon but a five-year trend of underperformance. This has culminated in its market cap weight in the S&P 500 dropping to 9%, the lowest level in three decades, signaling a significant, long-term investor rotation away from the industry.

Unlike labor-dependent services that get more expensive, prescription drugs offer a unique societal ROI because they eventually go generic and become cheaper. This deflationary aspect is a powerful, underappreciated argument for investing in drug development, as successful medicines provide compounding value to society over time.

Government subsidies within healthcare systems like the ACA create a perverse incentive for providers and insurers to inflate prices. This triggers a toxic flywheel: higher costs demand more subsidies, which in turn fuel further price hikes, making the underlying problem of affordability worse over time.

Drug Pricing Is Now a Bipartisan Issue, Creating Persistent Uncertainty for Healthcare Investors | RiffOn