While short-term keto adaptation (first month) may show no power gains, long-term adaptation (6-18 months) trains muscles to efficiently use fat as fuel. This results in significant power increases, with studies on soldiers showing up to a 50% improvement over their non-keto counterparts.

High-stakes mental tasks are physically taxing; a top chess player can burn 600 calories sitting at a board. Physical conditioning is not just for athletes; it directly builds gray matter and enhances executive function, providing the stamina needed to make good decisions under cognitive stress in a professional environment.

Instead of chasing weight loss, focus on foundational health markers like inflammation, blood sugar balance, stress levels, and nutrient deficiencies. When these systems are optimized, sustainable weight loss and body recomposition often occur as a natural side effect.

Many chronic illnesses, including high blood pressure, cancer, and cognitive decline, are not separate issues but symptoms of a single underlying problem: chronically elevated insulin levels. This metabolic “trash” accumulates over years, making the body a breeding ground for disease.

When addressing hormone imbalances, start at the base of the "hormone pyramid." Optimizing foundational hormones like cortisol (stress) and insulin (blood sugar) is essential, as they directly impact thyroid function and sex hormones like estrogen and testosterone.

A 7-year study of healthy individuals over 85 found minimal genetic differences from their less healthy counterparts. The key to their extreme healthspan appears to be a robust immune system, which is significantly shaped by lifestyle choices, challenging the common narrative about being born with "good genes."

Dr. D'Agostino gives his aging, neutered dogs a Selective Androgen Receptor Modulator (SARM) to stimulate muscle protein synthesis and maintain vitality. This approach is analogous to Testosterone Replacement Therapy (TRT) in humans, aiming to counteract the loss of skeletal muscle mass associated with aging and hormonal changes.

The body restricts movement into ranges where it is weak to protect itself from injury. By actively training for strength at the full extent of your motion (e.g., full-depth squats), you signal to your nervous system that the range is safe, which in turn increases your functional flexibility.

A typical sweet breakfast (cereal, juice, smoothie) creates a massive morning glucose spike, triggering a day-long cycle of cravings and fatigue. Switching to a savory breakfast built around protein stabilizes glucose levels from the start, providing steady energy and eliminating cravings.