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  1. Being a Life Sciences Leader
  2. Kris Vaddi, PhD, Prelude Therapeutics
Kris Vaddi, PhD, Prelude Therapeutics

Kris Vaddi, PhD, Prelude Therapeutics

Being a Life Sciences Leader · Feb 18, 2026

Prelude Therapeutics CEO Kris Vaddi on the scientist-to-CEO journey, ruthless capital discipline, and leading with strategic clarity.

A Veterinary Degree Can Be a Strategic Entry Point for a Drug Development Career

An unconventional path, like veterinary medicine, can provide a unique and strategic foundation for a career in pharmaceuticals. Kris Vaddi chose it not for animal care, but to deeply understand the animal biology and medicine crucial for pre-clinical drug testing.

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Kris Vaddi, PhD, Prelude Therapeutics

Being a Life Sciences Leader·a day ago

Prioritize Biotech Programs Based on Time and Capital Needed for a Definitive Answer

In biotech, early data is often ambiguous. Instead of judging programs on potential, leaders must prioritize based on the time and capital required to reach a clear 'yes' or 'no' outcome. Indefinite 'gray zone' projects drain resources that could fund a winner.

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Kris Vaddi, PhD, Prelude Therapeutics

Being a Life Sciences Leader·a day ago

Scientist-Founders Must Overcome the 'One More Experiment' Mindset to Succeed as CEOs

Scientist-founders often believe one more experiment will prove their hypothesis. To succeed as a CEO, they must shift from scientific curiosity to ruthless capital discipline, killing unviable programs and building a team that challenges ideas, not just executes them.

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Kris Vaddi, PhD, Prelude Therapeutics

Being a Life Sciences Leader·a day ago

Biotech CEOs Thrive on Decisiveness, Capital Discipline, and Clarity Under Pressure

Beyond scientific knowledge, the most effective biotech CEOs possess a specific set of traits. They must be decisive, maintain ruthless capital discipline (even for small amounts), and consistently demonstrate strategic clarity, especially when facing the immense pressure inherent in the industry.

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Kris Vaddi, PhD, Prelude Therapeutics

Being a Life Sciences Leader·a day ago

A Biotech CEO Must Evolve From Scientist and Storyteller to Adaptable Strategist

In the early stages, a biotech CEO's role is primarily scientific leadership and storytelling to attract investors. As the company and market mature, the role shifts. Effective CEOs must then become adaptable strategists, staying true to their core vision while responding to the dynamic industry environment.

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Kris Vaddi, PhD, Prelude Therapeutics

Being a Life Sciences Leader·a day ago

The CEO's Job Is Part Scientist, Investor, and Operator—but Full-Time Decision Maker

A CEO wears many hats—scientist, investor, operator—but their primary, non-delegable function is decision-making. This role requires integrating input from a leadership team that thinks at an enterprise level, enabling the CEO to make the final call on capital, strategy, and people.

Kris Vaddi, PhD, Prelude Therapeutics thumbnail

Kris Vaddi, PhD, Prelude Therapeutics

Being a Life Sciences Leader·a day ago