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  1. No Priors: Artificial Intelligence | Technology | Startups
  2. The Best of 2025 (So Far) with Sarah Guo and Elad Gil
The Best of 2025 (So Far) with Sarah Guo and Elad Gil

The Best of 2025 (So Far) with Sarah Guo and Elad Gil

No Priors: Artificial Intelligence | Technology | Startups · Oct 31, 2025

AI leaders discuss reasoning models, job displacement, geopolitical risks, and the profound human impact of today's AI breakthroughs.

Moderna Co-founder: Entrepreneurship Should Be a Science, Not a Random 'Game'

Nubar Afayan argues against the popular notion of entrepreneurship as a random, "gamey" process of wins and losses. He advocates for transforming it into a serious profession with systematic processes, especially for critical sectors like healthcare and climate, where a simple "shots on goal" approach is insufficient.

The Best of 2025 (So Far) with Sarah Guo and Elad Gil thumbnail

The Best of 2025 (So Far) with Sarah Guo and Elad Gil

No Priors: Artificial Intelligence | Technology | Startups·4 months ago

Glean CEO: Platform Shifts Like SaaS Can Revive 'Graveyard' Markets

Arvind Jain explains that the "graveyard" market of enterprise search became viable due to the platform shift to SaaS. Previously, accessing siloed, on-premise data was impossible for a turnkey product. SaaS provided standardized APIs, solving the core data access problem and turning a bad market into a good one.

The Best of 2025 (So Far) with Sarah Guo and Elad Gil thumbnail

The Best of 2025 (So Far) with Sarah Guo and Elad Gil

No Priors: Artificial Intelligence | Technology | Startups·4 months ago

Merkur CEO: Physical World Jobs Will Be a Refuge From Digital AI Displacement

Brendan Foodie predicts that as AI automates digital roles, the displaced workforce will shift to physical world jobs (from robotics data creation to therapy). He argues this is because physical automation progresses much slower than digital automation, which benefits from rapid, self-reinforcing feedback loops.

The Best of 2025 (So Far) with Sarah Guo and Elad Gil thumbnail

The Best of 2025 (So Far) with Sarah Guo and Elad Gil

No Priors: Artificial Intelligence | Technology | Startups·4 months ago

Abridge CEO: 'Oxytocin Hits' From Human Impact Outweigh 'Dopamine Hits' From Growth

Shiv Rao of Abridge highlights that the most motivating feedback for his AI healthcare tool isn't about growth metrics but about human impact. Stories of doctors avoiding burnout and spending time with family provide "oxytocin hits" of purpose that sustain the team more than the "dopamine hits" of hyper-growth.

The Best of 2025 (So Far) with Sarah Guo and Elad Gil thumbnail

The Best of 2025 (So Far) with Sarah Guo and Elad Gil

No Priors: Artificial Intelligence | Technology | Startups·4 months ago

Parvy Proved GPT-3's Legal Skills With a Simple Reddit Test, Surprising OpenAI

Parvy's founders validated their idea by applying GPT-3 to 100 legal questions from Reddit. They sent the AI-generated answers to attorneys, who approved 86% without edits. This simple, real-world test was so effective it surprised even OpenAI's own legal team about their model's capabilities.

The Best of 2025 (So Far) with Sarah Guo and Elad Gil thumbnail

The Best of 2025 (So Far) with Sarah Guo and Elad Gil

No Priors: Artificial Intelligence | Technology | Startups·4 months ago