AI models are trained on large lab-generated datasets. The models then simulate biology and make predictions, which are validated back in the lab. This feedback loop accelerates discovery by replacing random experimental "walks" with a more direct computational route, making research faster and more efficient.
Instead of being standalone institutes, CZI's Biohubs in San Francisco, Chicago, and New York are deeply integrated with elite universities like Stanford, Northwestern, and Columbia. This strategic model provides immediate access to world-class talent, research infrastructure, and collaborative opportunities, forming the "magic of the model."
CZI operates with a philosophy of open science, rejecting a proprietary model. The organization actively makes its discoveries, datasets, and tools publicly available, often before formal publication. The stated goal is not to own breakthroughs, but to empower the entire scientific community to build upon their work and accelerate progress collectively.
CZI's philosophy is to pursue transformative, paradigm-shifting medical advances. The organization explicitly avoids incremental improvements, such as extending a cancer patient's life by a few months. Instead, it directs all its resources towards ambitious goals like outright curing or preventing diseases, fostering a culture of "unbridled ambition."
While acknowledging the power of Large Language Models (LLMs) for linear biological data like protein sequences, CZI's strategy recognizes that biological processes are highly multidimensional and non-linear. The organization is focused on developing new types of AI that can accurately model this complexity, moving beyond the one-dimensional, sequential nature of language-based models.
To study complex processes like inflammation, CZI is developing technologies that go beyond analyzing existing data. This includes implantable sensors that track inflammatory markers in real-time (like a glucose monitor) and "live tissue omic platforms" that can map entire proteomes, creating rich, dynamic datasets to train advanced AI models.