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  1. The a16z Show
  2. Big Ideas 2026: New Infrastructure Primitives
Big Ideas 2026: New Infrastructure Primitives

Big Ideas 2026: New Infrastructure Primitives

The a16z Show · Dec 26, 2025

Exploring new foundational rails: on-chain credit origination, autonomous science labs, and startups targeting other startups at formation.

The 'Greenfield Strategy': Win Distribution by Growing With Newly Formed Startups

Sell to startups at their inception when they have no switching costs and few stakeholders. As these customers scale into major companies, your business scales with them, turning early adopters into significant, long-term revenue streams.

Big Ideas 2026: New Infrastructure Primitives thumbnail

Big Ideas 2026: New Infrastructure Primitives

The a16z Show·2 months ago

AI in Scientific Research Requires Interpretability, Not Just Performance

For AI systems to be adopted in scientific labs, they must be interpretable. Researchers need to understand the 'why' behind an AI's experimental plan to validate and trust the process, making interpretability a more critical feature than raw predictive power.

Big Ideas 2026: New Infrastructure Primitives thumbnail

Big Ideas 2026: New Infrastructure Primitives

The a16z Show·2 months ago

Synthetic On-Chain Assets Scale More Easily Than Tokenizing Real-World Assets

Creating synthetic derivatives (like perpetual futures) of traditional assets on-chain is more scalable and efficient than creating direct tokenized copies. This is especially true for assets with high derivative demand, such as emerging market equities.

Big Ideas 2026: New Infrastructure Primitives thumbnail

Big Ideas 2026: New Infrastructure Primitives

The a16z Show·2 months ago

Incumbents' P&L Models Prevent Them From Selling to Early-Stage Startups

Large incumbents struggle to serve newly-formed startups because these customers offer low initial revenue but require significant sales and support. This P&L constraint creates a protected 'greenfield' market for new vendors to capture customers early and grow with them.

Big Ideas 2026: New Infrastructure Primitives thumbnail

Big Ideas 2026: New Infrastructure Primitives

The a16z Show·2 months ago